PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

seminar talks:

Aging in the hematopoietic compartment (Kirschner)

Beyond clocks - the inner workings of DNA methylation dynamics (Chandra)

Dr. Kirschner’s lab deciphers how age‑driven alterations in hematopoietic stem cells fuel blood cancer risk. Her pioneering work combines single‑cell multiomics with population studies to build predictive tools for clonal hematopoiesis and explore senescence dynamics—advancing strategies to intercept age‑related disease

Dr. Chandra’s interdisciplinary research harnesses genomics, AI, and quantitative biology to unravel the molecular basis of epigenetic aging, senescence, and clonal mosaicism. His team probes how epigenetic clocks may be reset via partial reprogramming in blood, and applies AI-driven tools to stratify patient risk and rejuvenate aging phenotypes.

title: tba

Seminar talk by Dr. Daphne S. Cabianca from Helmholtz Zentrum, Munich.

Dr. Daphne S. Cabianca leads the Environment and Nuclear Organization group at Helmholtz Munich’s Institute of Functional Epigenetics. Her research focuses on how environmental cues—such as temperature or nutrient availability—reshape chromatin organization and gene expression. Using C. elegans as a model, her team combines CRISPR-based genome engineering, live imaging, and sequencing approaches to uncover how spatial chromatin dynamics contribute to cellular adaptation.